The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical\r\nproducts. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative nontoxic\r\nnatural products or adjuvants that serve as antidotes are in high demand. We have investigated the effects of\r\nAyurvedic herb Ashwagandha (Withania somnifera) leaf extract on methoxyacetic acid (MAA) induced toxicity. MAA is a\r\nmajor metabolite of ester phthalates that are commonly used in industry as gelling, viscosity and stabilizer reagents. We\r\nreport that the MAA cause premature senescence of normal human cells by mechanisms that involve ROS generation, DNA\r\nand mitochondrial damage. Withanone protects cells from MAA-induced toxicity by suppressing the ROS levels, DNA and\r\nmitochondrial damage, and induction of cell defense signaling pathways including Nrf2 and proteasomal degradation.\r\nThese findings warrant further basic and clinical studies that may promote the use of withanone as a health adjuvant in a\r\nvariety of consumer products where the toxicity has been a concern because of the use of ester phthalates.
Loading....